High Protein Chicken Bake

Featured in: Everyday Main Dishes

This Mediterranean-inspired chicken bake features tender breasts topped with a creamy layer of Greek yogurt, spinach, garlic, and mozzarella. The cherry tomatoes add sweetness while baking, creating a sauce-like consistency. With 40 grams of protein per serving and only 8 grams of carbs, it fits perfectly into high-protein and low-carb eating plans. The entire dish comes together in just 10 minutes of prep time and 25 minutes in the oven.

The yogurt mixture keeps the chicken moist while adding tangy flavor, and the melted mozzarella creates a golden, bubbly topping. This bakes beautifully in a 400°F oven, producing juicy chicken that reaches perfect doneness. Let it rest for 5 minutes before serving to allow the juices to redistribute.

Great for meal prep as it reheats well, and pairs wonderfully with roasted vegetables or cauliflower rice for a complete meal.

Updated on Sat, 07 Feb 2026 14:17:00 GMT
Freshly baked High Protein Chicken Bake topped with bubbly mozzarella, golden tomatoes, and vibrant spinach on a ceramic plate. Save to Pinterest
Freshly baked High Protein Chicken Bake topped with bubbly mozzarella, golden tomatoes, and vibrant spinach on a ceramic plate. | vectorgrill.com

I threw this together on a Tuesday evening when I was tired of bland chicken and staring at a tub of Greek yogurt in my fridge. The combination sounded strange at first, but something about the creamy yogurt melting into the warm spinach just worked. Now it is the one recipe my coworkers actually ask me to bring to potlucks.

Last summer my sister came over to help me meal prep for the week. We made three batches of this chicken bake, laughing while trying to evenly spread the yogurt mixture and probably eating more tomatoes than made it into the dish. She still texts me every time she makes it for her family now.

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Ingredients

  • Boneless skinless chicken breasts: Pound them to even thickness so they cook at the same rate
  • Greek yogurt: Use plain nonfat or lowfat for that creamy texture without the extra calories
  • Low fat mozzarella cheese: Just enough to add a subtle melty layer on top
  • Fresh spinach: Chopped finely so it incorporates into the yogurt mixture beautifully
  • Cherry tomatoes: They roast down into little bursts of sweetness while baking
  • Garlic: Minced fresh releases more flavor than garlic powder ever could
  • Italian seasoning: A simple blend that ties everything together without extra work
  • Olive oil: Lightly grease your dish to prevent any sticking
  • Salt and pepper: Season generously since the yogurt needs a little help bringing out all the flavors

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Instructions

Heat things up:
Preheat your oven to 400°F and lightly grease an 8x8 baking dish with olive oil
Mix the creamy topping:
Combine Greek yogurt, garlic, spinach, mozzarella, Italian seasoning, salt, and pepper in a bowl until everything is well incorporated
Arrange the chicken:
Place your chicken breasts in the prepared dish, spacing them evenly so heat can circulate
Spread the goodness:
Divide the yogurt mixture over each piece of chicken, spreading it to the edges
Add the tomatoes:
Scatter halved cherry tomatoes around and on top for pops of roasted flavor
Bake until perfect:
Cook for 20 to 25 minutes until chicken reaches 165°F internally and the top turns golden
Let it rest:
Give the dish 5 minutes to settle before serving so the juices redistribute
Savory High Protein Chicken Bake from the oven, featuring a creamy Greek yogurt crust and juicy, tender chicken breasts. Save to Pinterest
Savory High Protein Chicken Bake from the oven, featuring a creamy Greek yogurt crust and juicy, tender chicken breasts. | vectorgrill.com

This recipe became my go-to when I started seriously tracking my protein intake but refused to eat another dry, boring chicken breast. The way the yogurt keeps everything tender while packing in that extra protein made it feel like I had discovered a secret hack.

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Making It Your Own

Kale or Swiss chard work beautifully if you want to switch up the greens. Sometimes I add a pinch of red pepper flakes when I want a little warmth, or fresh basil from my windowsill garden right before serving.

Perfect Pairings

I love serving this with roasted vegetables or cauliflower rice for a complete low carb meal. The dish is substantial enough to stand alone with a simple side salad if you are keeping things light.

Meal Prep Magic

This chicken bake keeps incredibly well in the refrigerator for up to four days. The flavors actually develop overnight and taste even better for lunch the next day.

  • Store individual portions in glass containers for easy grab and go meals
  • Reheat gently in the microwave covered with a damp paper towel
  • The yogurt mixture prevents the chicken from drying out when reheated
Healthy High Protein Chicken Bake served with fresh spinach and roasted cherry tomatoes, perfect for an easy weeknight dinner. Save to Pinterest
Healthy High Protein Chicken Bake served with fresh spinach and roasted cherry tomatoes, perfect for an easy weeknight dinner. | vectorgrill.com

Hope this becomes one of those reliable recipes you turn to when you want something healthy but refuse to compromise on flavor.

Recipe Questions & Answers

Can I use frozen spinach instead of fresh?

Yes, frozen spinach works well. Thaw it completely and squeeze out excess moisture before mixing with the Greek yogurt to prevent the topping from becoming watery.

What temperature should the chicken reach?

The chicken is safe to eat when it reaches an internal temperature of 165°F (74°C). Use a meat thermometer inserted into the thickest part of the breast to check doneness.

Can I prepare this ahead of time?

Absolutely. Assemble the dish up to 24 hours in advance, cover tightly, and refrigerate. When ready to bake, you may need to add 5-10 extra minutes to the cooking time.

What can I substitute for Greek yogurt?

Sour cream or plain regular yogurt can be used, though Greek yogurt provides the best protein content and thickness. For a dairy-free option, try a dairy-free Greek-style yogurt alternative.

How do I store leftovers?

Store cooled leftovers in an airtight container in the refrigerator for up to 4 days. Reheat in the microwave or oven at 350°F until warmed through.

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High Protein Chicken Bake

Tender oven-baked chicken with creamy Greek yogurt topping, fresh spinach, and cherry tomatoes. High protein, low carb, and ready in 35 minutes.

Prep Time
10 mins
Time to Cook
25 mins
Overall Time
35 mins
Created by Chloe Moore


Skill Level Easy

Cuisine Type Mediterranean

Makes 4 Portions

Dietary Info No Gluten, Reduced-Carb

What You’ll Use

Protein & Dairy

01 1 lb boneless, skinless chicken breasts
02 1/2 cup Greek yogurt, plain non-fat or low-fat
03 1/4 cup low-fat mozzarella cheese, shredded

Vegetables

01 1 cup fresh spinach, chopped
02 1/2 cup cherry tomatoes, halved
03 2 cloves garlic, minced

Seasonings & Oils

01 1 tbsp olive oil
02 1 tsp Italian seasoning
03 Salt and freshly ground black pepper, to taste

How-To

Step 01

Preheat Oven: Preheat oven to 400°F. Lightly grease a baking dish with olive oil.

Step 02

Prepare Yogurt Mixture: In a medium bowl, combine Greek yogurt, minced garlic, chopped spinach, shredded mozzarella, Italian seasoning, salt, and pepper. Stir until well mixed.

Step 03

Arrange Chicken: Arrange chicken breasts in the prepared baking dish.

Step 04

Add Topping: Evenly spread the yogurt-spinach mixture over the top of each chicken breast.

Step 05

Add Tomatoes: Scatter the halved cherry tomatoes around and on top of the chicken.

Step 06

Bake: Bake for 20–25 minutes, or until the chicken reaches an internal temperature of 165°F and the top is lightly golden.

Step 07

Rest and Serve: Remove from oven and let rest for 5 minutes before serving.

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What You’ll Need

  • Oven
  • Baking dish (approx. 8x8 inch)
  • Mixing bowl
  • Knife and cutting board
  • Measuring cups and spoons

Allergy Info

Look over each item for allergens and check with your doctor if unsure.
  • Contains dairy (Greek yogurt, mozzarella)
  • Always check labels if using pre-shredded cheese or packaged yogurt for hidden allergens

Nutrition Breakdown (per portion)

Nutrition data is for learning only—not a substitute for professional medical advice.
  • Caloric Value: 400
  • Fats: 18 g
  • Carbohydrates: 8 g
  • Proteins: 40 g

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